Topical steroid and NSAID combo provides optimal CME prophylaxis-PREMED study

The first report from the ESCRS PREMED study has provided evidence supporting the use of a combination of topical corticosteroid and a topical nonsteroidal anti-inflammatory drug (NSAID) to prevent cystoid macular oedema (CME) after cataract surgery in nondiabetic patients.

The study comprised 914 patients randomised to receive topical bromfenac 0.09% twice daily for two weeks, a tapering dose of dexamethasone 0.1%, or a combination of both. The study showed that at six weeks postoperatively, patients in the bromfenac and dexamethasone group had significantly greater reductions in macular thickness than the other two groups.

In addition, the incidence of clinically significant CME during the first 12 weeks postoperatively was only 1.5% in the combination group compared to 5.1% in the dexamethasone monotherapy group.



About the Portal

With our new range of online resources, you can continue your education year-round with ESCRS.

All of our resources together in one place:

  • iLearn (online CME accredited courses)
  • On Demand (A new updated layout for ease of use)
  • Player (videos from many different categories)
  • Landmark Journal Articles
  • Case Studies
  • Course Handouts and more…
Read more