Virtual Refractive Surgery for the Prevention Of Negative Dysphotopsia (“vRESPOND”) study

Project leader: Dr. Jan Willem Beenakker, Leiden The Netherlands

Amount awarded by ESCRS: €650,195 | STATUS: PROJECT COMPLETED

vRESPOND Project Summary

The overall goal of the vRESPOND study is to provide a clinically feasible and cost-effective

Method to manage negative dysphotopsia (ND). We aim to use MRI-based patient-specific eye-models to uncover the underlying optical origin of ND through ray-tracing simulations. We subsequently aim to develop a Virtual Refractive Surgery application for the prevention and treatment of ND.

In terms of specific research aims:

  • comprehensive clinical evaluation will be made of 60 ND patients and 60 pseudophakic controls both in terms of objective ophthalmic measurements and standardized questionnaires.
  • Based on these data, ray-tracing analyses will be performed using the patient-specific, MRI-based, eye-models to:
    1. elucidate the mechanism for ND
    2. determine the key aspects of IOL design to prevent ND
    3. develop the Virtual Refractive Surgery model to preoperatively select high-risk patients and guide to the optimal IOL-type to prevent ND for these high-risk patients.

vRESPOND Media Resources

Increased peripheral spherical aberrations are present in patients with negative dysphotopsia

Presenter: J.W. Beenaker, Netherlands | Session: Free Paper Session: Biometry & Quality of Vision (36th Congress of the ESCRS 2018)

Negative Dysphtopsias

Presenter: G. Luyten Netherlands Session: Main Symposium: The Unhappy Pseudophakic Patient (37th Congress of the ESCRS 2019)

Peripheral aberrations in negative dysphotopsia

Presenter: L. van Vught, Netherlands | Session: Free Paper Session: Cataract Surgery Complications (37th Congress of the ESCRS 2019)

Uncovering the origin of negative dysphotopsias with MRI: the ESCRS vRESPOND study

Presenter: J.W. Beenaker, Netherlands Session: Clinical Research Symposium: Understanding and Dealing with Dysphotopsia (37th Congress of the ESCRS 2019)

vRESPOND Publication(s)

May 2020The evolution of ophthalmic imaging

Ophthalmologists currently have at their fingertips an impressive array of imaging tools for diagnosing disease, guiding interventions, and managing outcomes. These tools are a key part of everyday practice in anterior segment surgery, particularly cataract and refractive surgery, corneal transplantation, keratoconus, glaucoma and ocular surface disease.

Read Article

Past/Present ESCRS Research Projects


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