Virtual Refractive Surgery for the Prevention Of Negative Dysphotopsia (“vRESPOND”) study

Method to manage negative dysphotopsia (ND). We aim to use MRI-based patient-specific eye-models to uncover the underlying optical origin of ND through ray-tracing simulations. We subsequently aim to develop a Virtual Refractive Surgery application for the prevention and treatment of ND.

In terms of specific research aims:

• comprehensive clinical evaluation will be made of 60 ND patients and 60 pseudophakic controls both in terms of objective ophthalmic measurements and standardized questionnaires.
• Based on these data, ray-tracing analyses will be performed using the patient-specific, MRI-based, eye-models to:
  1. elucidate the mechanism for ND
  2. determine the key aspects of IOL design to prevent ND
  3. develop the Virtual Refractive Surgery model to preoperatively select high-risk patients and guide to the optimal IOL-type to prevent ND for these high-risk patients.