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METAgenomics guided treatment of CORneal infections –an interventional blinded randomized clinical trial

Microbial keratitis are one of the most severe emergencies in ophthalmology and a world leading cause of preventable blindness. Diagnosis is challenging due to the multitude of possible pathogens mimicking similar clinical presentations. Sensitivity of traditional culture-based assays usually ranges from 40 to 70 %.

 

Next Generation Sequencing (NGS) technology will be used to study the microbial communities directly in their natural environment, through whole genome sequencing, switching from cultured to uncultured genetic-guided diagnosis is the more appropriate diagnostic approach towards microbial keratitis. Samples will be obtained using scrapes, swabs and impression membranes and will be sent to the laboratory for NGS and CDM. The metagenomic tests will be performed on the samples using high-throughput platforms, such as Illumina HiSeq2500 and MiSeq.

Clinical impact will be revolutionary, because ophthalmologists will have information on the precise microbiota/microbiome of all samples rather than the 40% of those from which an organism has been isolated.

 

Further details can be found here: https://education.escrs.org/metagenomics/#

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Latest ESCRS EuroTimes Podcasts

DateTitleSummary
Oct 2020
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Eye JC: Episode 5

This journal club will be hosted by Basak Bostanci Ceran (Turkey) and Artemis Matsou (Greece). Guest Panellists for this episode are Oliver Findl (Austria) and Vincent Qin (Belgium).   The article for this episode is: “Development of a reliable preoperative risk stratification system for phacoemulsification” https://journals.lww.com/jcrs/Abstract/2020/08000/Development_of_a_reliable_preoperative_risk.11.aspx

Sep 2020
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Eye JC: Episode 4

This journal club is hosted by Artemis Matsou (UK) and Imran Yusuf (UK). Guest panellists for this episode are Béatrice Cochener-Lamard (France) and Vasilios Diakonis (Greece). The article for this episode is: “Comparison of femtosecond laser–assisted cataract surgery and conventional cataract surgery: a meta-analysis and systematic review” https://journals.lww.com/jcrs/Fulltext/2020/08000/Comparison_of_femtosecond_laser_assisted_cataract.3.aspx?context=FeaturedArticles&collectionId=1

Sep 2020
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Corneal endothelium and phakic IOLs: problems and solutions, with Roberto Bellucci

Sorcha Ní Dhubhghaill talks to Roberto Bellucci about corneal endothelium and phakic IOLs.

Aug 2020
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Eye JC: Episode 3

This is an audio recording of Episode 3 of ‘Eye JC: An online Journal Club brought to you by ESCRS’ This journal club is hosted by Basak Bostanci Ceran (Turkey) and Imran Yusuf (UK). We are delighted to welcome guest panellists Wolfgang Mayer (Germany) and Medhi Shajari (Germany). The third journal club covered the following paper: “Risk factors for dropped nucleus in cataract surgery as reflected by the European Registry of Quality Outcomes for Cataract and Refractive Surgery. Journal of Cataract & Refractive Surgery. 2020 Feb 1;46(2):287-92.” This paper has been made open-access by the JCRS.    

Aug 2020
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Performing complex surgery, with Boris Malyugin

Nic Reus talks to Boris Malyugin about the challenges and complications of complex cataract surgery.

Aug 2020
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What can we look forward to in the next generation of IOLs, with Jesper Hjordtal

Sean Henahan talks to Jesper Hjortal about what we can look forward to in the next generation of IOLs

Aug 2020
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Everything you ever wanted to know about phaco in small eyes, with Soosan Jacob

Sean Henahan interviews Soosan Jacob about some tips for performing phaco in small eyes.

Aug 2020
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When should we use EDOF IOLs, with David Spalton

The latest in EDOF lenses, how they work, and which ones to use.

Aug 2020
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Addressing the unhappy pseudophakic patient, with Rudy Nuijts

Anders Behndig speaks to Rudy Nuijts about some techniques to minimise and reduce the problem of the unhappy pseudophakic patient. 

Aug 2020
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Eye JC: Episode 2

This is a recording of Episode 2 of ‘Eye JC: An online Journal Club brought to you by ESCRS’ Episode 2 discusses the following paper: “Risk of posterior capsular rupture during phacoemulsification cataract surgery in eyes with previous intravitreal antivascular endothelial growth factor injections” This journal club is hosted by Basak Bostanci Ceran (Turkey) and Imran Yusuf (UK). We are delighted to welcome guest panellists Adi Abulafia (Israel) and Thomas Kohnen (Germany).

Jul 2020
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Ocular Surface Imaging , with Marc Labetoulle

Dan Epstein talks to Marc Labetoulle about the latest developments in Ocular Surface Imaging.

Jul 2020
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Cataract Surgery In Trauma Patients, with Basak Bostanci

Aidan Hanratty talks to Basak Bostanci Ceran about cataract surgery in trauma patients and the importance of carrying out specific assessments of these patients before surgery.

Jul 2020
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Latest Optical Refinements In Refractive IOLs, with Filomena Ribeiro

Thomas Kohnen interviews Filomena Ribeiro about the latest in refractive IOLs. Does she see  accommodative IOLs on the horizon? 

Jul 2020
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Eye JC: An online Journal Club brought to you by ESCRS. Episode 1

This is a recording of Episode 1 of ‘Eye JC: An online Journal Club brought to you by ESCRS’ The ESCRS has launched on online journal club, where interesting articles will be discussed by our Young Ophthalmologists Committee, with guest ‘expert opinion’ from ESCRS Board & Committee Members. This journal club is hosted by Basak Bostanci Ceran (Turkey) and Imran Yusuf (UK). We are delighted to welcome guest panellists Boris Malyugin (Russia) and Sathish Srinivasan (UK). Episode 1 discusses the following paper: “Pupil expansion device use and operative outcomes with topical dilation vs intracameral epinephrine in resident-performed cataract surgery” This paper has been made open-access by the JCRS. Click here for access.

Jul 2020
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How to get the best results for your IOL patients, with Nino Hirnschall

Sean Henahan talks to Nino Hirnschall about how biometry can optimise outcomes for cataract surgery patients.

Jul 2020
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PREMED Study one year on, with Laura Wielders

Oliver Findl talks to Laura Wielders about the findings from the landmark ESCRS PREvention of Macular EDema after cataract surgery (PREMED) study and the follow-up research which is now being carried out (originally released June 2019).   Full details about the study can be found here: https://education.escrs.org/prevention-of-macular-edema-after-cataract-surgery-premed-study-portal/    

Jul 2020
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The EPICAT study: Effectiveness of Periocular drug Injection in CATaract surgery’

In Europe, over 4 million cataract surgeries are performed each year. A major cause of suboptimal vision following cataract surgery is cystoid macular edema (CME). In patients with CME, fluid accumulates in the central retinal area, due to leakage of blood vessels. Multiple cyst-like (cystoid) areas of fluid appear in the retina and cause retinal swelling or edema. Symptoms of CME are blurred and decreased vision. Anti-inflammatory eye drops are used after cataract surgery to prevent CME. However, noncompliance with eye drops is a major issue and may compromise the effectiveness of treatment.   Noncompliance is often unintentional and related to forgetfulness or incorrect instillation, particularly in the elderly cataract surgery population. Because many patients have difficulty with self-instillation of eye drops, formal or informal care is often required. Administrating anti-inflammatory drugs with an injection in or around the eye during cataract surgery may obviate the need for eye drops after surgery.   To investigate the effectiveness of anti-inflammatory drug delivery in or around the eye during cataract surgery, we propose to conduct a study in which 540 patients scheduled for cataract surgery will participate. Patients will be randomly divided over 3 treatment groups. One group will receive standard anti-inflammatory eye drops after cataract surgery. The other groups will receive a single or a combination of two anti-inflammatory drugs by injection in or around the eye during cataract surgery.   Before and after cataract surgery we will measure the thickness of the central area of the retina, and compare this between groups. In addition, visual acuity and quality of life will be evaluated. We expect that administration of anti-inflammatory drugs during cataract surgery improves vision and comfort for patients and decreases costs. It may also alleviate the burden on homecare organizations.    

Jul 2020
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What I Wish I Knew When I Was An Ophthalmology Trainee, with Sorcha Ní Dhubhghaill

Richard Packard talks to Sorcha Ní Dhubhghaill about preparing for a future career in ophthalmology.

Jun 2020
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Influence of posterior vitreous detachment on retinal detachment after lens surgery in myopic eyes (MYOPRED)

Sean Henehan talks to Oliver Findl about this ongoing clinical research project, sponsored by ESCRS.

Jun 2020
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Cataract Surgery In Eyes With Diseased Corneas, with Jesper Hjortdal

Massimo Busin talks to Jesper Hjortdal about performing cataract surgery in eyes with diseased corneas.

Jun 2020
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The vRESPOND study: Virtual REfractive Surgery for the Prevention Of Negative Dysphotopsia

The overall goal of the vRESPOND study is to provide a clinically feasible and cost-effective method to manage negative dysphotopsia (ND). The study aim to use MRI-based patient-specific eye-models to uncover the underlying optical origin of ND through ray-tracing simulations. They subsequently aim to develop a Virtual Refractive Surgery application for the prevention and treatment of ND. In terms of specific research aims:  comprehensive clinical evaluation will be made of 60 ND patients and 60 pseudophakic controls both in terms of objective ophthalmic measurements and standardized questionnaires.  Based on these data, ray-tracing analyses will be performed using the patient-specific, MRI-based, eye-models to: elucidate the mechanism for ND determine the key aspects of IOL design to prevent ND develop the Virtual Refractive Surgery model to preoperatively select high-risk patients and guide to the optimal IOL-type to prevent ND for these high-risk patients   Further details: https://education.escrs.org/virtual-refractive-surgery-for-the-prevention-of-negative-dysphotopsia-vrespond-study/

Jun 2020
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Phakic intraocular lenses in the management of keratoconus with José Güell

Aidan Hanratty talks to José Güell about the use of phakic IOLs in the management and treatment of keratoconus.

Jun 2020
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The NECSUS Study – Neuroadaptation after Cataract and Refractive Surgery, with Joaquim Murta

This study aims, for the first time, to identify changes in neural activity patterns after multifocal IOL implantation overtime and their relation with objective and qualitative aspects of visual function. Such information will provide valuable knowledge on the identification of therapeutic targets and of intraocular lens characteristics that are more likely to trigger neuroadaptation circuits effectively and, hence, lead to practical clinical use.   More information on the study can be found here: https://education.escrs.org/necsus-neuroadaptation-after-cataract-and-refractive-surgery-study/

Jun 2020
00.00.00
How to review a scientific paper, tips for reviewers from JCRS European Editor Professor Thomas Kohnen

JCRS Associate European Editor Sathish Srinivasan talks to JCRS European Editor Thomas Kohnen about why peer review is important for ophthalmologists and how to peer review.

May 2020
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Everything You Ever Wanted To Know About Phaco For Beginners, with Soosan Jacob

Sean Henahan talks to Soosan Jacob about preparing for your first phacoemulsification and how to reduce the stress from the experience for both surgeon and patient.

May 2020
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Visual Retinal Image Quality with Raymond Applegate

Quality of vision following any kind of refractive surgery matters most to patients. But how do we measure this, and how do evaluate the outcomes of various refractive surgical interventions in a comparative way? Marie-José Tassignon discusses this important topic with Dr Ray Applegate, of the University of Houston, Texas (recorded 2017)

May 2020
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Corneal Topography with Cynthia Roberts

Dan Epstein talks to Cynthia Roberts about what’s new in corneal topography and also some of the misconceptions and misinterpretations when talking about topography. For more information on Corneal Topography visit ESCRS iLearn for a course directed by Prof Roberts.

May 2020
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The right IOL for trauma cases, with Gábor Scharioth

Boris Malyugin talks to Gábor Scharioth about points to consider when choosing which IOL to use in traumatic cataract cases.

May 2020
00.00.00
Phaco tips for improving your surgery, with Khiun Tjia

Dr. Tjia gives beginners some tips on where they can improve their techniques and outcomes.

May 2020
00.00.00
OCT for corneal imaging: clinical and intraoperative applications with Mohammed Belmekki

Paul Rosen talks to Mohammed Belmekki about the clinical and intraoperative applications of OCT in corneal imaging.

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